Esej poskuša izslediti pravni, reprezentativni in družbeni status migrantskih Drugih v ≫zaprti družbi≪ Nemške demokratične republike ali Vzhodne Nemčije (NDR) kot primer, kako je Nemčija imela dobiček od delovnih migracij na obeh straneh zidu. Opisuje, kako so bile od ponovne združitve Nemčije do danes migracije predstavljene kot nenadna in začasna težava, kar zakriva kolonialno in rasistično preteklost ter nekropolitično sedanjost. Esej preučuje proces družbene dediferenciacije v družbi, ki jo obvladuje država NDR, in kako so družbene tehnike ustvarjanja drugosti in etnizacije (...) v obliki zakonov za tujce spodbujale diskriminacijo in rasizem proti ≫tujcu≪ (Simmel), zlasti gastarbajterem. Ob pogledu na proces ≫dvojne transformacije≪ po padcu berlinskega zidu in poznejši ponovni združitvi esej preučuje, kako so prekrivajoči se procesi ustvarjanja drugosti kot sodobnega ekvivalenta izraza ≫orientalizem≪ (Edward Said) oblikovali in še naprej oblikujejo ponovno združeno Nemčijo. (shrink)

A unique Middle English text on the seven liberal arts survives in Cambridge, Trinity College, MS R. 14.52, a manuscript of ca. 1458–85. Latin texts on the seven liberal arts were certainly in circulation in medieval England, but this text is, to my knowledge, the earliest one written in English. It thereby offers evidence of the vernacular English reader's knowledge of the arts that were the foundation of medieval university education. This text is also unique in that it includes in (...) its chapter on grammar an attempt to describe the phonetic production of the letters of the alphabet, providing the only surviving contemporary approximation of the pronunciation of medieval English, and in that it adds a chapter on the mechanical sciences, relating them as no other medieval author to the English craft guilds. (shrink)

Background: No studies have examined the underlying structure or predictive validity of the Cognitive Therapy Adherence and Competence Scale. Examining the structure of the CTACS is of great relevance because it could provide information on what constitutes competence in CBT, and whether some underlying factors are more important for predicting treatment outcomes than others. This study investigates the psychometric properties of the Norwegian version of CTACS and its associations with treatment outcomes in a sample of primary care clients who received (...) CBT for anxiety and/or depression.Method: Independent assessors rated audiotaped therapy sessions in a sample of 132 primary care clients, participating in the Prompt Mental Health Care trial. Outcomes were symptoms of anxiety and depression assessed by patient self-report questionnaires. Structural validity was examined by means of confirmatory and exploratory factor analyses, whereas longitudinal associations with treatment outcome were explored by adopting multilevel modeling.Results: No evidence was found for the divergent validity of the constructs competence and adherence as indicated by a very high correlation between these two subscales in CTACS. Regarding reliability, ICCs for the mean score of the full competence scale and its associated subscales were generally good to excellent, although the subscale measuring the quality of the therapeutic relationship was relatively low. Internal consistency was overall acceptable, but our CFA models did not provide an acceptable fit for the pre-specified one-factor and four-factor solutions. EFA results were difficult to interpret, with a sub-optimal three-factor solution providing best model fit and only two meaningful factors [CBT specific skills and session structure ]. Overall, the results indicated no evidence for the scales' predictive validity.Conclusion: Our findings point to several psychometric problems of the CTACS that may limit both its research and clinical utility. The importance of providing empirical evidence for both reliability and validity aspects of scales are discussed and suggestions for future research are provided. (shrink)

Dossier: L’humilité Présentation du dossier. Coordonné par Elisa Grimi. Essays and contributors: L’intelligence de l’humilité, Carla Canullo; La virtù dell’umiltà e l’eudemonismo, Mario Micheletti; Humility – A work of love?, Katharine Opalka; L’humilité intellectuelle, la foi et l’épistémologie, Roger Pouivet; L’irriducibile ragionevolezza di un paradosso. L’umiltà secondo Tommaso d’Aquino e Gilbert K. Chesterton, Marco Salvioli, O.P.; L’Humilité, une ontologie de l’identité, Elisa Grimi.

Europa, cristianità, istruzione, educazione, società secolare, tempi moderni. Questi e molti altri ancora i temi che Rémi Brague affronta tin questo volume. Il continuo processo di individualizzazione, caratterizzato dal razionalismo, ha comportato un totale indebolimento dei legami societari e ha posto al centro le libertà e i diritti dei singoli. Si assiste così all’evoluzione di una società secolarizzata che giunta al suo capolinea non riesce più a bastare a se stessa. Il pensiero moderno non sembra essere in grado di giustificare (...) il fatto che esistono degli uomini sulla terra, cercando di costruire unicamente sul proprio terreno senza considerare ciò che trascende l’umano, Natura o Dio. “Il progetto dei Tempi moderni è fallito. L’ateismo è incapace di rispondere alla questione della legittimità dell’uomo”. Brague insiste nel mettere in rilievo il carattere missionario del cristianesimo: questo – scrive – non è riservato esclusivamente agli europei. Si chiede quindi Brague se la nostra società abbia ancora il desiderio di vivere e di agire e auspica che tale desiderio sia destato, attingendo alla sorgente della vita. Contro il cristianismo e l’umanismo si presenta come una originale riflessione sulla società di oggi, attenta a non nascondere l’aspirazione propria di ciascun individuo, per cui è legittimo parlare di ciò che veramente è ‘umano’ e di una dimensione spirituale che caratterizza ciascuna cultura. (shrink)

IntroductionIn this study we compared the effects of a mindfulness-based intervention with a story reading intervention on the executive functions and psychological profile of children in two different public schools in São Paulo, Brazil.MethodsIn this controlled clinical trial, 207 children aged 8 to 9 years old responded to the Five-Digit Test, stress levels, depression, anxiety, positive and negative affect, at baseline and 8 weeks later. From T0 to T1, school 1 participated in MBI classes and school 2 in IS classes.ResultsIn (...) school 1, children improved their scores on all tests except reading and counting compared with school 2. No differences were observed between groups in terms of emotional health.ConclusionIt is feasible to implement MBI or SI in Brazilian public schools. Students in the MBI group presented broader effects in executive functions, while students in the SI group showed a trend toward reduced negative affect and depression symptoms. (shrink)

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

The book is an introduction to key concepts of Indian Philosophy, seen from the perspective of the influential school of Pr?bh?kara M?m??s? (flourished from the 7th until the 20th c. AD). It includes the edition and translation of R?m?nuj?c?rya's ??straprameyapariccheda.

Weatherson argues that whoever accepts classical logic, standard mereology and the difference between vague objects and any others, should conclude that there are no vague objects. Barnes and Williams claim that a supporter of vague objects who accepts classical logic and standard mereology should recognize that the existence of vague objects implies indeterminate identity. Even though it is not clearly stated, they all seem to be committed to the assumption that reality is ultimately constituted by mereological atoms. This assumption is (...) not granted by standard mereology which instead remains silent on whether reality is atomic or gunky; therefore, I contend that whoever maintains classical logic, standard mereology and the difference between vague objects and any others, is not forced to conclude with Weatherson that there are no vague objects; nor is she compelled to revise her point of view according to Barnes and Williams’s proposal and to accept that the existence of vague objects implies indeterminate identity. (shrink)

BackgroundPeople with upper extremity amputations report receiving insufficient information about treatment options. Furthermore, patients commonly report not knowing what questions to ask providers. A question prompt sheet, or list of questions, can support patient-centered care by empowering patients to ask questions important to them, promoting patient-provider communication, and increasing patient knowledge. This study assessed information needs among people with UE amputations about UE vascularized composite allotransplantation and developed a UE VCA-QPS.MethodsThis multi-site, cross-sectional, mixed-methods study involved in-depth and semi-structured interviews with (...) people with UE amputations to assess information needs and develop a UE VCA-QPS. Qualitative data were analyzed by thematic analysis; quantitative data were analyzed by descriptive statistics. The initial UE VCA-QPS included 130 items across 18 topics.ResultsEighty-nine people with UE amputations participated. Most were male, had a mean age of 46 years, and had a unilateral and below-elbow amputation. Participants desired information about UE VCA eligibility, evaluation process, surgery, risks, rehabilitation, and functional outcomes. After refinement, the final UE VCA-QPS included 35 items, across 9 topics. All items were written at a ≤ 6th grade reading level. Most semi-structured interview participants reported being ‘completely’ or ‘very’ likely to use a UE VCA-QPS.ConclusionPeople with UE amputations have extensive information needs about UE VCA. The UE VCA-QPS aims to address patients’ information needs and foster patient-centered care. Future research should assess whether the UE VCA-QPS facilitates patient-provider discussion and informed decision-making for UE VCA. (shrink)

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together (...) researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals. (shrink)

Ve?ka?an?tha was the most important systematiser of the Vi?i???dvaita school of Ved?nta. This article describes his use of Buddhist sources and shows how Ve?ka?an?tha reused Buddhist texts to a much more significant extent than his predecessors Y?muna and R?m?nuja. The reused text-passages come mostly from the epistemological school of Buddhist philosophy but there are important exceptions, attesting that Ve?ka?an?tha was also aware of Buddhist schools such as the Vaibh??ikas, of whom only little is preserved today. Given that Buddhist philosophy was (...) no longer an active presence in South India at the time of Ve?ka?an?tha, his interest in it must be due to factors other than his polemical agenda. Perhaps, his project of enlarging Vi?i???dvaita Ved?nta made him confront outsiders such as Buddhist thinkers and his intellectual interest in philosophy made him engage in a genuine confrontation with them. (shrink)

La categoría ‘arte conceptual’ se aplica a una gran cantidad de obras de arte contemporáneo. El artista Sol LeWitt introdujo el término en la jerga del arte al describir obras de arte donde “la idea o el concepto es el aspecto más importante de la obra” (LeWitt 1967: 79, traducción mía). Inicialmente, el término se utilizó para referirse a obras producidas entre finales de los años sesenta y principios de los setenta por artistas como Sol LeWitt, Robert Barry, Lawrence Weiner, (...) On Kawara, Joseph Kosuth, John Baldessari, el grupo Art & Language y otros (véase Lippard 1973). En España fueron relevantes el Grup de Treball, Zaj o Esther Ferrer entre otros. Más tarde se hizo evidente no solo que obras como Fuente (1917) de Marcel Duchamp – un urinario de porcelana, que fue firmado “R. Mutt” y presentado para una exposición de la Sociedad de Artistas Independientes – tenían mucho en común con aquellas producidas a finales de la década de 1960 y principios de la de 1970, sino también que obras de arte conceptual continuaron siendo producidas a lo largo de la década de 1970 y las décadas siguientes, hasta el punto de que podría argumentarse que gran parte del arte contemporáneo es, en cierta medida, conceptual. -/- Es característico de los primeros autores conceptuales el uso del lenguaje natural en obras que son en principio visuales o plásticas, como las frases de Weiner, las definiciones de Kosuth o los ensayos de Art&Language. Se trata de un interés por el significado y el lenguaje heredado de la semiótica y la filosofía analítica de la época. También señala el énfasis (a menudo exclusivo) de todas las obras de arte conceptual en el elemento conceptual, como ocurre en los dibujos y pinturas murales de LeWitt, donde el artista produjo las instrucciones para su ejecución, luego las realizó en colaboración con otros, o transfirió completamente a otros esta tarea. Otra característica de las primeras obras de arte conceptual es que los artistas no manipularon ningún material para producir un objeto (como en Fuente de Duchamp) o usaron materiales excéntricos como el lenguaje natural, su propio cuerpo -como en I am the locus (# 1) (1975) de Adrian Piper, una performance en la que la artista se pegó un bigote en la cara, se puso una peluca Afro y anteojos redondos con montura de alambre y caminó en las calles actuando como un hombre-, o el chocolate con el que Anya Gallaccio revistió las paredes de un viejo edificio agrícola en Stroke (2004), dejando que el público las tocara y que el chocolate se pudriese. -/- Debido a sus características inusuales, el arte conceptual plantea muchas preguntas filosóficas: sobre la definición de arte, sobre la ontología y los medios de las obras de arte y sobre nuestra experiencia apreciativa de ellas. En lo que sigue, presentaré brevemente cada uno de estos temas. (shrink)

L’origine della storia dell’Europa merita di essere ripercorsa. Troppo spesso infatti si tralascia il fatto che la cultura europea è secondaria ad Atene e Gerusalemme. Nel presentare lo scenario attuale si ragiona spesso sul collante monetario che tiene uniti gli stati, sulla buona morale che li accomuna aperta alla convivenza con l’estraneo, tuttavia non si considera mai il fatto che l’ethos ha ragioni storiche. Si parla di diritti, si erige l’eguaglianza a principio sovrano, trascurando che la Dichiarazione Universale che tutela (...) tali diritti non è stata accettata da una parte significativa di mondo. E ancora si parla spesso di bilancio demografico nazionale e integrazione, ignari dell’ipotesi recentemente avanzata di un’Europa balcanizzata. E infine si trascura che l’ethos di un popolo trova il suo inizio in una credenza e dunque in una tradizione. In questo breve saggio tenterò di tratteggiare brevemente l’odierno quadro europeo, mettendo in evidenza i legami forti, imprescindibili, sui quali poggia l’etica di una civiltà, e con essa i diritti che la società tutela e promuove. Tenterò altresì di porre in evidenza la trasformazione in atto a livello sociale circa l’etica occidentale consentita, il suo “legittimo” allargamento, e sul perché si ritenga corretto promuoverla. Keywords: Europa, Cristianesimo, Bene, Male, Diritto, Dichiarazione dei diritti umani (1948), Dichiarazione del Cairo (1990), Sacro. Bibliography/Authors: R. Brague, J. Ratzinger, J. Habermas, J. Weiler, M.A. Glendon, Z. Bauman, O. Rey. (shrink)

BackgroundPsychological support was provided by the Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol within the hospitals in the Northern Italy in favor of healthcare workers during the COVID-19 pandemic. This study aimed at evaluating the effectiveness of treatment in terms of symptomatology reduction related to peri- and post-traumatic stress; clinical improvement over time; and the maintenance of the achieved outcome over time.MethodsThe population was composed of healthcare workers who spontaneously requested psychological intervention in both the first and the (...) second emergency waves. Statistical analyses were carried out to highlight the differences in Impact of Event-Revised and Post-Traumatic Growth Inventory before and after the group intervention.ResultsIn both the first and the second waves, pre-treatment values are higher than post-treatment values for all dimensions of the IES-R. The results show that there are no significant differences between the first and the second wave with regard to the treatment effect. Healthcare workers maintained positive changes over time despite their prolonged exposure to an emergency and the possibility of retraumatization at the onset of a new emergency phase, irrespective of their working place. Healthcare workers who were treated in the first wave showed at the beginning of the second emergency wave less vulnerability and more resilience than those who were treated only in the second wave.Pre-treatment scores of healthcare workers affected by COVID-19 are discussed.ConclusionCOVID-19 had a significant impact on the well-being of healthcare workers who were working in hospitals. Psychological support in case of emergency is needed. (shrink)

Biomedical research policy in recent years has often tried to make such research more ‘translational’, aiming to facilitate the transfer of insights from research and development to health care for the benefit of future users. Involving patients in deliberations about and design of biomedical research may increase the quality of R&D and of resulting innovations and thus contribute to translation. However, patient involvement in biomedical research is not an easy feat. This paper discusses the development of a method for involving (...) patients in biomedical research aiming to address its main challenges. (shrink)

Recent studies reported the development of psychological distress symptoms in patients who recovered from COVID-19. However, evidence is still scarce and new data are needed to define the exact risk and protective factors that can explain the variability in symptoms manifestation. In this study, we enrolled 257 patients who recovered from COVID-19 and we evaluated the levels of psychological distress through the Symptoms Checklist-90-R scale. Data concerning illness-related variables were collected from medical records, while the presence of subjective cognitive difficulties, (...) both before and after the illness, as well as the level of the cognitive reserve, were assessed over a clinical interview. Results revealed that being female and reporting the presence of subjective cognitive difficulties after COVID-19 were associated with higher levels of psychological distress. At the same time, being admitted to the hospital and having a high CR were protective factors. Adding new information to this emerging research field, our results highlight the importance of a complete psychological and cognitive assessment in patients with COVID-19. (shrink)

The changes and general alarm of the current COVID-19 pandemic have amplified the sense of precariousness and vulnerability for family members who, in addition to the emotional trauma of the cancer diagnosis, add the distress and fear of the risks associated with infection. The primary objectives of the present study were to investigate the psychological impact of the COVID-19 pandemic on the parents of pediatric cancer patients, and the level of stress, anxiety, and the child’s quality of life perceived by (...) the parents during the COVID-19 epidemic. The parents of 45 consecutive children with solid and hematological tumors were enrolled. Four questionnaires were administered to the parents at the beginning of the pandemic lockdown. A 75% of parents exhibited remarkable levels of anxiety, with 60 subjects in state scale and 45 subjects in trait scale having scores that reached and exceeded the STAI-Y cut off. The bivariate matrix of correlation found a significant positive correlation between the IES-R and PSS scores. There was a positive correlation between the PSS and PedsQL scale and a negative correlation between IES-R and STAI-Y. The results confirm that parents of pediatric cancer patients have a high psychological risk for post-traumatic symptoms, high stress levels, and the presence of clinically significant levels of anxiety. (shrink)

Background: Prior research has explored reasons why health care providers may or may not choose to seek an ethics consultation. Although low-quality communication is evident in many ethics consultations, it is unknown whether poor communication in clinical settings is related to health care providers' requests for ethics involvement. Objective: To assess the relationship between self-reported ratings of health care providers' inter- and intraprofessional communication and ethics consultation requests. Method: This cross-sectional survey was conducted using a self-administered questionnaire of physicians and (...) nurses in six intensive care units at one academic medical center in the United States. The questionnaire assessed perceptions about requesting ethics consultations and how health care providers perceive communication. Results: Two hundred sixty-two participants (228 nurses and 34 physicians) responded to the survey (response rate 55%; 59% for nurses and 41% for physicians). Requests for an ethics consult were positively associated with perceived quality of interprofessional communication (r =.13, p <.05), but perceptions of the number of ethical dilemmas that occur on participants' units each month were negatively associated with the perceived quality of intra-professional communication (r = −.17, p <.01). Conclusion: The relationship that was hypothesized between perceived poor communication and increased number of ethics consultations was not borne out by these data. Indeed, we found the opposite; these finding suggests that good inter- and intraprofessional communication may promote the use of outside resources, such as ethics, when they are needed. (shrink)

Research misconduct is an alarming concern worldwide, and especially in Italy, where there is no formal training of young researchers in responsible research practices. The main aim of this study was to map the perceptions and attitudes about RM in a sample of young researchers attending a one-week intensive course on methodology, ethics and integrity in biomedical research, held at the University of Insubria. To this end, we administered the Scientific Misconduct Questionnaire to all attendees at the beginning of the (...) course. Thereafter, SMQ-R was re-administered at the end, to assess the impact of the course on the responsiveness of study participants, which is intended as the frequency of responses other than “don’t know”. Results show that respondents rate as high their own understanding about rules and procedures related to scientific misconduct, as well as the effectiveness of their institution’s measures for reducing it. Most of them perceive as low the chances of getting caught for RM. Some respondents believe that cases of misconduct occur in their workplace and that the integrity of a research is not solely the responsibility of the principal investigator. Among the main factors contributing to research misconduct, the need for publications, unclear definition of what constitutes misconduct and pressure for external funding do stand out. Respondents are concerned about the amount of misconduct and express a pressing need for training on research ethics. Remarkably, the responsiveness of participants tends to increase with course attendance. This finding may be useful to support education programmes devoted to research methodology, ethics and integrity among young researchers. (shrink)

Biomedical research policy in recent years has often tried to make such research more ‘translational’, aiming to facilitate the transfer of insights from research and development to health care for the benefit of future users. Involving patients in deliberations about and design of biomedical research may increase the quality of R&D and of resulting innovations and thus contribute to translation. However, patient involvement in biomedical research is not an easy feat. This paper discusses the development of a method for involving (...) patients in biomedical research aiming to address its main challenges.After reviewing the potential challenges of patient involvement, we formulate three requirements for any method to meaningfully involve patients in biomedical research. It should enable patients to put forward their experiential knowledge, to develop a rich view of what an envisioned innovation might look like and do, and to connect their experiential knowledge with the envisioned innovation. We then describe how we developed the card-based discussion method ‘Voice of patients’, and discuss to what extent the method, when used in four focus groups, satisfied these requirements. We conclude that the method is quite successful in mobilising patients’ experiential knowledge, in stimulating their imaginaries of the innovation under discussion and to some extent also in connecting these two. More work is needed to translate patients’ considerations into recommendations relevant to researchers’ activities. It also seems wise to broaden the audience for patients’ considerations to other actors working on a specific innovation. (shrink)

Various types of plant species have been extensively used for heavy metals phyto-remediation without taking into consideration its tolerance threshold. In this study, Vetiver grass, Vetiveria zizanioides (Linn.) Nash was evaluated under five different sets of contaminated spiked cadmium (5Cd, 10Cd, 50Cd, 100Cd and 150Cd mg/kg) and lead (50Pb, 100Pb, 200Pb, 400Pb and 800Pb mg/kg) concentration levels in soil. The growth performance, metal tolerance and phyto-assessment of Cd and Pb in the roots and tillers were assessed using flame atomic (...) absorption spectrometry (FAAS). Tolerance index (TI), translocation factor (TF), biological transfer factor (BTF), biological accumulation coefficient (BAC) and metal uptake efficacy were used to determine the Cd and Pb translocation capability in Vetiver grass. Significantly higher (p<0.05) accumulation of Cd and Pb was recorded in the roots of all spiked treatments. Furthermore, strong and significantly positive correlations were exhibited between the increased levels of spiked heavy metal concentrations with both Cd (r=0.975) and Pb (r=0.952) accumulations. The results of this study showed Vetiver grass as an effective phyto-stabilizer for both Cd and Pb. Nevertheless, the growth of Vetiver grass was restricted when the tolerance threshold of 100 mg/kg (dry weight basis) Cd was exceeded in the contaminated soil. (shrink)

Most phyto-remediation studies have been conducted merely on a single type of contaminant element without consideration of the influence of other co-existent contaminants. In this study, Vetiveria zizanioides (Linn.) Nash was evaluated in both single and mixed heavy metal (Cd, Pb, Cu and Zn) spiked contaminated soil. The plant growth, metal accumulation and overall efficiency of metal uptake by different plant parts (lower root, upper root, lower tiller and upper tiller) were investigated in detail. The relative growth performance, metal (...) tolerance and phyto-assessment of heavy metal in roots and tillers of Vetiver grass were assessed. Metals in plants were measured using the flame atomic absorption spectrometry (F-AAS) after acid digestion. The root-tiller (R/T) ratio, tolerance index (TI), translocation factor (TF), biological concentration factor (BCF), biological accumulation coefficient (BAC) and metal uptake efficacy were estimated to examine the ability of metal accumulation and translocation in Vetiver grass. No significant difference (p > 0.05) of plant height was observed among all single and mixed heavy metal spiked soils compared with the control. However, significantly higher (p < 0.05) heavy metal (Cd, Pb, Cu and Zn) accumulations were found in roots, tillers and overall total accumulation of the individual spiked metal as compared with other treatments. Vetiver grass grown in the mixed Cd + Pb + Cu + Zn spiked soils accumulated the highest Zn (3322 ± 21.6 mg/kg) followed by Cu (430 ± 11.4 mg/kg), Pb (197 ± 13.5 mg/kg) and Cd (100 ± 0.7 mg/kg). Vetiver grass grown in mixed Cd + Pb, Cu + Zn and Cd + Pb + Cu + Zn spiked soils accumulated higher heavy metal concentrations than from the single spiked soil with the following order of metals: Zn > > Cu > Pb > Cd. Moreover, lower roots and lower tillers of Vetiver grass revealed a strong tendency for greater uptake and accumulation of all four heavy metals in both single and/or mixed spiked contaminated soils. -/- . (shrink)

The emerging concept of systems medicine (or ‘P4 medicine’—predictive, preventive, personalized and participatory) is at the vanguard of the post-genomic movement towards ‘precision medicine’. It is the medical application of systems biology, the biological study of wholes. Of particular interest, P4 systems medicine is currently promised as a revolutionary new biomedical approach that is holistic rather than reductionist. This article analyzes its concept of holism, both with regard to methods and conceptualization of health and disease. Rather than representing a medical (...) holism associated with basic humanistic ideas, we find a technoscientific holism resulting from altered technological and theoretical circumstances in biology. We argue that this holism, which is aimed at disease prevention and health optimization, points towards an expanded form of medicalization, which we call ‘holistic medicalization’: Each person’s whole life process is defined in biomedical, technoscientific terms as quantifiable and controllable and underlain a regime of medical control that is holistic in that it is all-encompassing. It is directed at all levels of functioning, from the molecular to the social, continual throughout life and aimed at managing the whole continuum from cure of disease to optimization of health. We argue that this medicalization is a very concrete materialization of a broader trend in medicine and society, which we call ‘the medicalization of health and life itself’. We explicate this holistic medicalization, discuss potential harms and conclude by calling for preventive measures aimed at avoiding eventual harmful effects of overmedicalization in systems medicine (quaternary prevention). (shrink)